"Shiny Happy People" is a song by the American rock band R.E.M., released as the second single from their seventh studio album, Out of Time (1991). It features guest vocals by Kate Pierson of the B-52's, who also appears in the music video. It was used as the theme song for the unaired pilot of the sitcom Friends, before it was replaced by the Rembrandts' "I'll Be There for You"

Kaley Cuoco and Conan O'Brien really enjoy each other's company on his show. But when he offers to hang out with Kaley and her fiancé, the mood suddenly changes.